Treating HAE Attacks with KALBITOR

KALBITOR (ecallantide) is an under the skin (subcutaneous),
on-demand treatment for hereditary angioedema (HAE) attacks that targets and inhibits plasma kallikrein, which stops the production of bradykinin to reduce the pain and swelling of an HAE attack.

Please see Full Prescribing Information, including Boxed Warning and Medication Guide.

How KALBITOR (ecallantide) Works

What is KALBITOR?

KALBITOR is approved to treat hereditary angioedema (HAE) attacks in people 12 years of age and older. KALBITOR is not a cure for HAE.

KALBITOR is an on-demand treatment that targets plasma kallikrein.

How Does KALBITOR Work?

People with HAE have a protein in their body called plasma kallikrein that is not controlled properly. KALBITOR inhibits the activity of this protein, which stops the production of bradykinin, to reduce the pain and swelling of an HAE attack.

During an HAE Attack:

Untreated person with HAE during an attack.
  • A protein called plasma kallikrein triggers the release of another protein called bradykinin. The release of too much bradykinin causes small blood vessels to release fluid in certain parts of the body, resulting in the localized swelling and pain of an HAE attack.

After Treatment with KALBITOR:

Person with HAE after treatment with KALBITOR.
  • KALBITOR works by inhibiting plasma kallikrein, which stops the production of bradykinin to reduce the pain and swelling of an HAE attack.

Proven Results

People treated with KALBITOR showed significant improvement in HAE attack symptoms at 4 hours compared to patients who were treated with placebo.

About KALBITOR Injections

KALBITOR injections should only be given by a doctor or a nurse with appropriate medical support to manage serious allergic reactions and HAE. For each dose, your doctor or nurse will inject KALBITOR just under your skin, away from the site of the attack and into the abdomen, thigh, or upper arm.

Serious allergic reactions have been known to occur in people treated with KALBITOR. These reactions can be life-threatening and usually happen within 1 hour after receiving KALBITOR. See potential side effects.

Please read the Medication Guide before you start receiving KALBITOR and before each treatment. There may be new information.